weight loss

FDA-approved, long-term weight loss medications like

Semaglutide (Wegovy), Tirzepatide (Zepbound), and Liraglutide (Saxenda) effectively reduce appetite and promote significant weight loss (up to 22.5%). Other options include Phentermine-topiramate (Qsymia), Naltrexone-bupropion (Contrave), and Orlistat (Alli/Xenical). These are generally for BMI

≥is greater than or equal to

≥

30, or

≥is greater than or equal to

≥

27 with co-morbidities.

Top FDA-Approved Weight Loss Medications

- Tirzepatide (Zepbound): Injectable, high efficacy, averaging up to 22.5% weight loss.
- Semaglutide (Wegovy): Injectable, suppresses appetite, averaging up to 14.9% weight loss
  .

Liraglutide (Saxenda): Daily injection that slows gastric emptying, resulting in ~8% weight loss.

Phentermine-topiramate (Qsymia): Oral capsule that suppresses appetite, causing 7–11% weight loss.

Naltrexone-bupropion (Contrave): Oral tablet for cravings, causing 5–9% weight loss.

Orlistat (Xenical, Alli): Reduces dietary fat absorption; Alli is available over-the-counter.

Key Considerations

How They Work: Most enhance satiety (feeling full) or reduce hunger, with the exception of Orlistat, which blocks fat absorption.
Common Side Effects: Nausea, vomiting, diarrhea, constipation, headache, and dizziness are common.
Eligibility: Generally recommended for individuals with a BMI of 30 or higher, or 27 or higher with weight-related conditions like hypertension or type 2 diabetes.

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